GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | MLF1IP | chr4:185615220-185655286:- | 0.48 | 11.78 | 1.56E-27 | Kawasaki disease |
| BLCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | ADAL | chr15:43622872-43646094:+ | -0.42 | -5.24 | 2.69E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | CATSPER2 | chr15:43922774-43959900:- | -0.31 | -4.83 | 1.98E-6 | Tumor biomarkers |
| BLCA | cis | rs798766 | 1 | rs4865463 | chr4:1742400 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.5 | 9.09E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs798766 | 1 | rs4865467 | chr4:1745500 | FAM53A | chr4:1641609-1685854:- | 0.31 | 4.47 | 1.01E-5 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs4869313 | 1 | rs4869313 | chr5:96223880 | ERAP2 | chr5:96211644-96255398:+ | -0.91 | -24.1 | 9.16E-79 | Pediatric autoimmune diseases |
| BLCA | cis | rs2404602 | 1 | rs4886818 | chr15:76880939 | SCAPER | chr15:76640529-77197744:- | -0.21 | -4.67 | 4.18E-6 | Blood metabolite levels |
| BLCA | cis | rs2239557 | 1 | rs4903201 | chr14:74659690 | LIN52 | chr14:74551656-74667117:+ | -0.36 | -8.09 | 7.93E-15 | Common traits (Other) |
| BLCA | cis | rs2239557 | 1 | rs4903202 | chr14:74660302 | LIN52 | chr14:74551656-74667117:+ | -0.36 | -8.09 | 7.85E-15 | Common traits (Other) |
| BLCA | cis | rs2239557 | 1 | rs4903203 | chr14:74660508 | LIN52 | chr14:74551656-74667117:+ | -0.36 | -8.09 | 7.85E-15 | Common traits (Other) |
| BLCA | cis | rs11190179 | 1 | rs4919361 | chr10:101363707 | CNNM1 | chr10:101088856-101154085:+ | 0.34 | 3.86 | 0.000135 | β2-Glycoprotein I (β2-GPI) plasma levels |
| BLCA | cis | rs11190179 | 1 | rs4919367 | chr10:101366816 | CNNM1 | chr10:101088856-101154085:+ | 0.34 | 3.99 | 7.95E-5 | β2-Glycoprotein I (β2-GPI) plasma levels |
| BLCA | cis | rs9527 | 1 | rs4919690 | chr10:104616500 | C10orf32 | chr10:104613967-104624718:+ | 0.34 | 5.19 | 3.5E-7 | Arsenic metabolism |
| BLCA | cis | rs2028299 | 1 | rs4932148 | chr15:90394356 | AP3S2 | chr15:90373832-90456222:- | -0.69 | -10.24 | 6.77E-22 | Type 2 diabetes |
| BLCA | cis | rs10508921 | 1 | rs4935575 | chr10:52006165 | FAM21A | chr10:51827684-51893268:+ | -0.33 | -4.02 | 6.88E-5 | Thiazide-induced adverse metabolic effects in hypertensive patients |